Diagnostic comparison between FECPAKG2 and the Kato-Katz method for analyzing soil-transmitted helminth eggs in stool.

Diagnostic comparison between FECPAKG2 and the Kato-Katz method for analyzing soil-transmitted helminth eggs in stool.

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BackgroundOver one billion people are infected with soil-transmitted helminths (STH), i.e.Ascaris lumbricoides, hookworm and Trichuris trichiura.

For estimating drug efficacy and monitoring anthelminthic drug resistance, accurate diagnostic methods are critical.FECPAKG2 is a new remote-diagnostic tool used in veterinary medicine, which produces an image of the stool sample that can be stored on an internet cloud.We compared for the first time 6-0 igora vibrance FECPAKG2 with the recommended Kato-Katz method.

Methodology/principal findingsTwo stool samples were collected from adolescent participants (age 15-18 years) at baseline and 14 to 21 days after treatment in the framework of a randomized clinical trial on Pemba Island, Tanzania.Stool samples were analyzed with different diagnostic efforts: i) one or ii) two Kato-Katz thick smears from the first sample, iii) two Kato-Katz thick smears from two samples and iv) FECPAKG2 from the first sample.Parameters were calculated based on a hierarchical Bayesian egg count model.

Complete data for all diagnostic efforts were available from 615 participants at baseline and 231 hookworm-positive participants dea eyewear at follow-up.At baseline FECPAKG2 revealed a sensitivity of 75.6% (72.

0-77.7) for detecting A.lumbricoides, 71.

5% (67.4-95.3) for hookworm and 65.

8% (64.9-66.2) for T.

trichiura, which was significantly lower (all pConclusions/significanceThe sensitivity to identify any STH infection was considerably lower for FECPAKG2 compared to Kato-Katz.Following rigorous development, FECPAKG2 might be an interesting tool with unique features for epidemiological and clinical studies.